| 2335220 |
Salleh HM, Honek JF: Time-dependent inhibition of porcine kidney trehalase by aminosugars. FEBS Lett. 1990 Mar 26;262(2):359-62.
The inhibitory effects of various nitrogen-containing sugars on porcine kidney trehalase were studied. Validamycin A, validoxylamine A and MDL 25,637 were found to be potent, time-dependent inhibitors of the enzyme in vitro. The validoxylamine A-inhibited enzyme showed slow but reversible reactivation over time (t1/2 = 1.2 h). To our knowledge, this is the first report of time-dependent inhibition exhibited by either these particular aminosugars or a trehalase. |
3(0,0,0,3) |