| 10754204 |
Kishima MO, Barbisan LF, Estevao D, Rodrigues MA, Viana de Camargo JL: Promotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats. Cancer Lett. 2000 Apr 28;152(1):37-44.
The interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% energy-restricted diet, both added or not with 50 ppm HCB, for 6 weeks. HCB exposure or energy restriction separately did not exert any influence on the development of glutathione S-transferase placental form (GST-P (+)) foci of hepatocytes. Simultaneous HCB exposure and energy restriction induced a significant increase in liver centrilobular hypertrophy and GST-P (+) foci development. Our findings suggest that energy restriction increases liver response to low dose of HCB, unmasking the promoting potential of this fungicide. |
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