| 2283661 |
Mitra A, Richards I, Kitchin K, Conolly R, Kulkarni AP: Mirex induces ornithine decarboxylase in female rat liver. . J Biochem Toxicol. 1990 Summer;5(2):119-24.
Ornithine decarboxylase, the rate-limiting enzyme in polyamine synthesis, was significantly induced in female rat liver following oral administration of the pesticide mirex. After dual oral exposure (120 mg/kg of mirex; 21 and 4 hr prior to sacrifice), ornithine decarboxylase activity in rat liver cytosol was 70-fold higher than control values. A single oral dose of mirex (180 mg/kg) induced hepatic ornithine decarboxylase activity 55-fold over controls. After a single oral dose of mirex the maximal induction of ODC activity occurred at 36 hr. Mirex is an unusually potent and long-lasting inducer of rat hepatic ornithine decarboxylase activity. |
55(0,1,5,5) |