| 20298809 |
Tian H, Ru S, Wang W, Bing X: Effects of monocrotophos on the reproductive axis in the female goldfish (Carassius auratus). Comp Biochem Physiol C Toxicol Pharmacol. 2010 Mar 16.
Monocrotophos (MCP) is a highly toxic organophosphorus pesticide. To elucidate the influence of MCP on female fish reproduction, plasma 17beta-estradiol, testosterone and gonadotropin levels and aromatase and gonadotropin beta subunit gene expression levels were examined in female goldfish (Carassius auratus) following a 21-day exposure to 0.01, 0.10 and 1.00mgL-(1) 40% MCP-based pesticide in a semi-static exposure system. The results indicated that MCP induced increases in plasma 17beta-estradiol levels and the 17beta-estradiol/testosterone ratio via interference with the reproductive axis at multiple potential sites through two mechanisms: (a) MCP exposure enhanced the mRNA expression of gonadal aromatase, the enzyme that converts androgens into estrogens, consequently reducing plasma testosterone levels and increasing plasma concentrations of 17beta-estradiol; and (b) MCP treatment increased follicle-stimulating hormone beta subunit mRNA expression and secretion and decreased luteinizing hormone beta subunit mRNA expression and secretion, leading to the disruption of reproductive endocrine control and androgen and estrogen balance. This study provided convincing evidence for reproductive toxicology of MCP by disrupting of the HPG axis at multiple sites in female goldfish. |
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