Protein Information

ID 1662
Name 5 HT7
Synonyms 5 HT 7; 5 HT X; 5 HT X serotonin receptor; 5 HT7; 5 hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase coupled); 5 hydroxytryptamine 7 receptor; 5 hydroxytryptamine receptor 7; 5 hydroxytryptamine receptor 7 isoform d…

Compound Information

ID 1819
Name piperazine
CAS piperazine

Reference

PubMed Abstract RScore(About this table)
19560916 Zajdel P, Subra G, Verdie P, Gabzdyl E, Bojarski AJ, Duszynska B, Martinez J, Pawlowski M: Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4827-31. Epub 2009 Jun 13.
A series of arylsulfonamides containing guanidine incorporated in the structure of secondary amines (piperidine, piperazine) was synthesized on SynPhase Lanterns and evaluated for 5-HT (1A), 5-HT (2A), and 5-HT (7) receptors. The results demonstrated that N-alkyl-N'-dialkylguanidines displayed good 5-HT (7)/5-HT (1A) selectivity and may be regarded as promising structural core for development of 5-HT (7) ligands.		 83(1,1,1,3)