| 15713417 |
Yang C, Xu G, Li J, Wu X, Liu B, Yan X, Wang M, Xie Y: Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1505-7.
The synthesis of benzothiophenes containing a piperazine side chain and their binding affinities for estrogen receptors are described. These compounds bearing piperazine side chains were identified to be high-affinity ligands with high selectivity for ER alpha subtype. They were also potent agonists in bone tissue. |
243(3,3,3,3) |