| 11514156 |
Tagat JR, McCombie SW, Steensma RW, Lin S, Nazareno DV, Baroudy B, Vantuno N, Xu S, Liu J: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2143-6.
I: 2 (S)-methyl piperazine as a key pharmacophore element.. Optimization of the piperidino-piperazines 1 and 2 provided early leads 3 and 4, which showed good activity in the CCR5-RANTES binding assay and in antiviral assays. A systematic study around these structures showed that the 2 (S)-methyl piperazine is essential for CCR5 affinity, which is further enhanced by forming the 2,6-dimethyl benzamide of the piperidine. |
63(0,2,2,3) |