| 14572280 |
Olsen CA, Witt M, Jaroszewski JW, Franzyk H: Solid-phase polyamine synthesis using piperazine and piperidine building blocks. Org Lett. 2003 Oct 30;5(22):4183-5.
[reaction: see text]. Polyamines containing piperidine and piperazine moieties have been synthesized on solid support using SN2 alkylation of resin-bound secondary amines with 2-nitrobenzenesulfonates (nosylates). The effect of solvent on this alkylation was investigated. The methodology was employed for the total synthesis of novel analogues of wasp polyamine toxins (philanthotoxins). |
81(1,1,1,1) |