| 11605661 |
Komoto T, Okada T, Sato S, Niino Y, Oka T, Sakamoto T: New mu-opioid receptor agonists with piperazine moiety. Chem Pharm Bull. 2001 Oct;49(10):1314-20.
New mu-opioid receptor (MOR) agonists containing piperazine and homopiperazine moieties in the structures were synthesized and their affinities to and agonist potencies on MOR were evaluated. Among the synthesized compounds, 4-[4-(2-methoxyphenyl) piperazin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide (20 Aa) showed the highest affinity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells, and the highest agonist potency on the MOR in isolated guinea-pig ileum preparation. |
162(2,2,2,2) |