| 16289817 |
van den Hoogenband A, van Maarseveen JH, McCreary AC, Mulder AT, van Scharrenburg GJ, van Stuivenberg HH, Zethof TJ, Zijta B, Iwema Bakker WI: Piperazinyl oxime ethers as NK-1 receptor antagonists. . Bioorg Med Chem Lett. 2006 Feb 15;16(4):1045-8. Epub 2005 Nov 11.
The synthesis and structure-activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay. |
3(0,0,0,3) |