Protein Information

ID 4739
Name 5 HT1B
Synonyms 5 HT 1B; S12; 5 HT 1D beta; 5 HT1B; 5 HT1DB; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine 1B receptor; HTR1B…

Compound Information

ID 1819
Name piperazine
CAS piperazine

Reference

PubMed Abstract RScore(About this table)
18614422 Samad N, Haleem MA, Haleem DJ: Behavioral effects of 1-(m-chlorophenyl) piperazine (m-CPP) in a rat model of tardive dyskinesia. Pak J Pharm Sci. 2008 Jul;21(3):262-8.
The present study was designed to monitor the responsiveness of 5-hydroxy tryptamine (5-HT)-2C receptor in rats treated with haloperidol exhibiting tardive dyskinesia (TD). Results show that haloperidol injected at a dose of 1 mg/kg twice a day for two weeks elicited vacuous chewing movements (VCMs). Which increased in a time dependent manner following the drug administration for 3-5 weeks. The behavioral effects of 1-(m-chlorophenyl) piperazine (m-CPP) a 5-HT-2C and 5-HT-1B agonist were monitored 2 days after 5 weeks of saline or haloperidol administration. The results show that hypophagic as well as anxiogenic-like effects of m-CPP are greater in repeated haloperidol than repeated saline injected animals, while hypolocomotive effects of m-CPP are not different in repeated saline and haloperidol injected animals. Results are discussed in the context of role of 5-HT-2C receptors in the regulation of the activity of dopaminergic neuron and its possible impact on elicitation of TD.
31(0,1,1,1)