| 18996171 |
Ita ML, Cortes Mdel C, Valencia J, Eguibar JR: Activation of serotonin 5-HT1-receptors decreased gripping-induced immobility episodes in taiep rats. Neurosci Lett. 2009 Jan 9;449(2):147-50. Epub 2008 Oct 30.
The taiep rat is a myelin mutant that shows a disorganized sleep-wake cycle and immobility episodes (IEs) when the animals are gripped at the base of the tail. During IEs electroencephalographic recordings show a rapid eye movement (REM) sleep-like pattern. These alterations are quite similar to those reported in narcolepsy-cataplexy. Pharmacologically, systemic administration of alpha (2) adrenoceptor agonists increases gripping-induced IEs, whereas alpha (2) antagonists decrease them. However prazosin, an alpha (1) antagonist, increases gripping-induced IEs. In male 8-month-old taiep rats we have studied the effect of systemic administration of serotonergic autoreceptor agonists and antagonists on gripping-induced IEs. 8-Hydroxy-2-(di-n-propylamino) tetraline hydrobromide (8-OH-DPAT), a 5-HT (1A) agonist, and 3-trifluoromethylphenylpiperazine hydrochloride (TFMPP), a 5-HT (1B) agonist, produce a significant decrease in the frequency and mean duration of IEs. Systemic administration of spiperone and 1-(2-methoxyphenyl)-4 [4-(2-phthalimido) butyl] piperazine hydrobromide (NAN-190), 5-HT (1) antagonists, increase IEs and their mean duration. When the specific serotonin antagonist N-[2 [4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-2-pyridinyl-cyclohexanecar boxamide maleate (WAY 100635, 100 microg/kg) was injected 15 min before 8-OH-DPAT, this specific antagonist reverses the effects caused by the 5-HT (1A) agonist. These results show that serotonergic 5-HT (1)-receptors are involved in the susceptibility of gripping-induced IEs in taiep rats. Similar results have been reported in the food-elicited cataplexy test in narcoleptic dogs. |
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