| 14552781 |
Dyck B, Parker J, Phillips T, Carter L, Murphy B, Summers R, Hermann J, Baker T, Cismowski M, Saunders J, Goodfellow V: Aryl piperazine melanocortin MC4 receptor agonists. . Bioorg Med Chem Lett. 2003 Nov 3;13(21):3793-6.
Incorporation of substituted phenyl piperazine privileged structures into a known MC4 specific dipeptoid consensus sequence resulted in a series of potent (EC (50)=24 nM) and selective MC4-R agonists. We report the SAR of this series of compounds using in vitro cAMP functional assays in cells transfected with the MC4 or other melancortin receptors. |
31(0,1,1,1) |