Protein Information

ID 3805
Name serotonin receptor
Synonyms 5 hydroxytryptamine receptor 6; serotonin receptor; 5 HT 6; 5 HT6; 5 hydroxytryptamine (serotonin) receptor 6; 5 hydroxytryptamine 6 receptor; HTR 6; HTR6…

Compound Information

ID 1819
Name piperazine
CAS piperazine

Reference

PubMed Abstract RScore(About this table)
17892934 Tasler S, Kraus J, Wuzik A, Muller O, Aschenbrenner A, Cubero E, Pascual R, Quintana-Ruiz JR, Dordal A, Merce R, Codony X: Discovery of 5-HT6 receptor ligands based on virtual HTS. . Bioorg Med Chem Lett. 2007 Nov 15;17(22):6224-9. Epub 2007 Sep 8.
Based on a pharmacophore alignment on a 5-HT (6) ligand applying 4SCan technology, a new lead series was identified and further structurally investigated. K (i) s down to 8 nM were achieved.
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