| 15910816 |
Chilmonczyk Z, Sienicki L, Lozowicka B, Lisowska-Kuzmicz M, Jonczyk A, Aboul-Enein HY: Structure-retention relationship in a series of chiral 1,4-disubstituted piperazine derivatives on carbohydrate chiral stationary phases. Farmaco. 2005 May;60(5):439-43. Epub 2005 Apr 14.
New racemic 1,4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl-piperazine-1yl) carbonyl] C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris (4-methylbenzoate) and amylose tris (3,5-dimethylphenylcarbamate) stationary phases using hexane/propan-2-ol mobile phases. The optimum separation conditions for the compounds were obtained on cellulose tris (4-methylbenzoate) with 5% of 2-propanol in hexane. The relationship between structural and chromatographic parameters is discussed. |
31(0,1,1,1) |