| 3000030 |
Moser VC, MacPhail RC: Yohimbine attenuates the delayed lethality induced in mice by amitraz, a formamidine pesticide. Toxicol Lett. 1985 Nov;28(2-3):99-104.
We have found that a single dose of amitraz, a formamidine pesticide, produces death in mice 2-5 days after dosing. To further examine this phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600 mg/kg, i.p.) and twice daily thereafter for 8 days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an alpha 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz. |
81(1,1,1,1) |