| ID | 500 |
|---|---|
| Name | 3 beta hydroxysteroid dehydrogenase |
| Synonyms | 3 beta hydroxysteroid dehydrogenase; 3 beta hydroxysteroid dehydrogenase homolog protein; 3 beta hydroxysteroid dehydrogenase pseudogene; 3 beta hydroxysteroid dehydrogenase pseudogenes |
| ID | 182 |
|---|---|
| Name | endosulfan |
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 2553591 | Singh SK, Pandey RS: Gonadal toxicity of short term chronic endosulfan exposure to male rats. Indian J Exp Biol. 1989 Apr;27(4):341-6. Endosulfan was studied for its effect on rat testicular toxicity in relation to the enzymes of androgen biosynthesis, viz. 3 beta-hydroxysteroid dehydrogenase (EC 1.1.1.145, 3 beta-HSD) and 17 beta-hydroxysteroid dehydrogenase (EC 1.1.1.64, 17 beta-HSD); cytosolic conjugation enzyme, glutathione-S-transferase (EC 2.5.1.18); and testicular as well as serum levels at the dose levels of 2.5, 5.0, 7.5 and 10 mg/kg body weight fed orally for 7 and 15 days. Organ and body weights of the treated animals did not change significantly, however, the testicular protein contents were found to be increased appreciably after 7 days treatments. The activity profile of cytosolic conjugation enzyme showed much remained low during 7 days treatment, however, the two steroidogenic enzymes showed much individual variations in response to endosulfan treatments. An overall varied response with respect to biosynthesis and its secretion to serum was observed suggesting nevertheless, a profound hormonal imbalance caused by this insecticide to male gonads on short term chronic exposures. |
31(0,1,1,1) |