Protein Information

ID 59
Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

ID 182
Name endosulfan
CAS 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide

Reference

PubMed Abstract RScore(About this table)
11225895 Chitra KC, Latchoumycandane C, Mathur PP: Chronic effect of endosulfan on the testicular functions of rat. Asian J Androl. 1999 Dec;1(4):203-6.
AIM: To find out the toxic effect of endosulfan on the testicular function of pubertal rats. METHODS: Male rats of pubertal age were orally administered endosulfan at a dose of 1.0 mg/kg body weight for 30 days. Twenty-four hours after the last treatment, the rats were sacrificed and the testis, epididymis, seminal vesicles and ventral prostate were removed and weighed. A 10% testicular homogenate was prepared for biochemical estimations. RESULTS: In endosulfan-treated rats, there were a reduction in the body weight and the weights of testis and accessory sex organs, a decrease in the testicular lactate and pyruvate activities, and in the testicular DNA and RNA concentrations, whereas the testicular protein concentration was slightly increased; the specific activity of testicular steroidogenic enzyme, 3beta-OH-steroid dehydrogenase and the ascorbic acid level were decreased, which were correlated with a decrease in steroidogenesis. The lysosomal enzyme acid phosphatase and brush-border enzyme alkaline phosphatase activities were also decreased in the testis of treated rats. CONCLUSION: In pubertal rats, endosulfan treatment inhibits the testicular functions.
1(0,0,0,1)