| ID | 31 |
|---|---|
| Name | transferase |
| Synonyms | 4' phosphopantetheinyl transferase; 4' phosphopantetheinyl transferase; AASD PPT; AASDHPPT; AASDPPT; Alpha aminoadipic semialdehyde dehydrogenase phosphopantetheinyl transferase; Aminoadipate semialdehyde dehydrogenase phosphopantetheinyl transferase; CGI 80… |
| ID | 182 |
|---|---|
| Name | endosulfan |
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 1816080 | Singh SK, Pandey RS: potentiates in vivo hepatotoxicity of endosulfan in adult male rats. Indian J Exp Biol. 1991 Nov;29(11):1035-8. In an attempt to evaluate the effect and interaction of on endosulfan-induced hepatotoxicity in vivo to adult male rats, both, endosulfan (7.5 mg/kg body wt) and (1.5 g/kg body wt) were studied separately as well as in combination after a chronic oral exposure of 30 days. When fed separately, both the agents were found to induce microsomal mixed function oxidase (MFO) system in treated animals. A simultaneous induction in the activity of cytosolic GSH-s-transferase was found to be associated with significantly induced -induced microsomal lipid peroxidation. Both endosulfan and showed increasing trends in the activities of reducing equivalent -generating enzymes in liver. The activity of hepatic alcohol dehydrogenase was, however, found to be relatively unaffected. When was administered in combination with endosulfan, the observed effects on the activities of major drug metabolizing enzymes, microsomal lipid peroxidation and generation were further pronounced. Findings demonstrated the MFO inducing capability of both endosulfan and and showed further that chronic ingestion might potentiate the in vivo hepatotoxicity of endosulfan if administered in combination. |
1(0,0,0,1) |