| ID | 32 |
|---|---|
| Name | glycine receptor (protein family or complex) |
| Synonyms | Glycine receptor; Glycine receptors |
| ID | 182 |
|---|---|
| Name | endosulfan |
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 9432128 | Turner KO, Syvanen M, Meizel S: The human acrosome reaction is highly sensitive to inhibition by cyclodiene insecticides. J Androl. 1997 Nov-Dec;18(6):571-5. The mammalian sperm acrosome reaction (AR) is essential to fertilization. It can be initiated in vitro by a putative physiological initiator that helps to activate sperm (A) receptor/ channels and by a substitute for the egg zona pellucida, which activates sperm glycine receptor/ channels. Even at 1 nM (0.41 ng/ml or 0.41 ppb), chlordane and endosulfan, chlorinated cyclodiene blockers of insect neuronal (A) receptor/ channels, strongly inhibited the AR initiated by or Inhibition of the latter was also seen at 0.1 nM chlordane and endosulfan, but neither cyclodiene inhibited either AR initiator at 0.01 nM. Inhibitory concentrations of these cyclodienes are well within the range detected in human and wildlife tissue and fluids as a result of environmental contamination. |
1(0,0,0,1) |