cullin

General Information (Source: NCBI Gene,UniProt)

Text mining Term cullin
UniProt ID CSN5B_BRAOL
Name COP9 signalosome complex subunit 5b
Jun activation domain-binding homolog 1
Signalosome subunit 5b
Gene Names CSN5B
Synonyms:AJH1
Taxonomy Brassica oleracea

General annotation

Function Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1- containing Ubl ligase complexes (By similarity).
Subcellular location Cytoplasm. Nucleus.

Gene Ontology

GO:0008180 signalosome CC
GO:0007275 multicellular organismal development BP
GO:0009585 red, far-red light phototransduction BP
GO:0005737 cytoplasm CC
GO:0046872 metal ion binding MF
GO:0006508 proteolysis BP
GO:0008237 metallopeptidase activity MF

Sequence

>gi|55976235|sp|P68355.1|CSN5B_BRAOL RecName: Full=COP9 signalosome complex subunit 5b; Short=Signalosome subunit 5b; AltName: Full=Jun activation domain-binding homolog 1
VEQPDSSSSDGIFYYDEASQTKKISDDHVSEYQTIPLNKKQYYSLDITYFKSSLDSHLLDLLWNKKDILF
NSARQSDK

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