| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1DYI 2D0K 1RH3 1RX7 1RA1 1RB3 2ANO 2ANQ 1RA3 1JOM 1RX5 1RX2 1RX6 1RX9 5DFR 1RB2 1DYH 1RA9 1RX3 3DAU 1RC4 1DRB 1DYJ 2DRC 1TDR 1RX4 1RA8 1DHJ 1RX1 1DRA 2INQ 1DRH 3QL3 1DHI 1RG7 1RF7 1JOL 3K74 6DFR 1RE7 1RX8 1RD7 4DFR 3KFY 1RA2 3OCH 1DDR 3DRC 1DRE 1DDS 7DFR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |