dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0004146	dihydrofolate reductase activity	MF
GO:0042493	response to drug	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0050661	NADP binding	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0031427	response to methotrexate	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	2D0K 3KFY 1DRH 1DYJ 2ANO 1RE7 1RC4 1JOL 3K74 3QL3 1DYI 2ANQ 1RA1 5DFR 1RX6 1DRE 7DFR 1RX4 1RX9 3OCH 2DRC 1DDS 1DDR 1RA9 1RF7 1DRB 1RX5 1RH3 1RX2 1DRA 6DFR 2INQ 1TDR 1JOM 1RX7 1DHI 1RA8 1DYH 1RX1 1RA3 1RA2 1RG7 1RX3 1DHJ 1RX8 4DFR 3DRC 3DAU 1RD7 1RB3 1RB2
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference