| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RH3 2DRC 2ANQ 2ANO 1DRH 1JOL 3K74 7DFR 1RA9 1DYJ 1RE7 1RX7 1DRA 3QL3 1RG7 1JOM 2D0K 1TDR 1DYH 1RX9 1RD7 4DFR 3DRC 3OCH 1RC4 1DHI 2INQ 1RA2 6DFR 1RF7 1RB3 1DDS 1DRE 1RX2 1RX3 1RB2 1RX1 1RX6 3DAU 1RA8 1RA1 1DYI 1RA3 3KFY 1RX8 5DFR 1DDR 1RX4 1DRB 1DHJ 1RX5 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |