dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0031427	response to methotrexate	BP
GO:0050661	NADP binding	MF
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	2ANQ 1JOL 1RA3 3K74 3QL3 1RA1 1RB3 1RG7 1DYJ 1DHJ 3DAU 3OCH 1DYH 1RX8 1RX2 5DFR 1RA8 6DFR 1RX5 1TDR 3DRC 1RX3 7DFR 2ANO 1RD7 1DRE 1JOM 1RE7 1DDS 1DRA 1RX4 4DFR 3KFY 1RA2 1RH3 1RF7 1RX9 1RA9 1DRB 1DYI 2D0K 1DDR 1RX6 2DRC 1RX1 1DHI 1DRH 2INQ 1RC4 1RB2 1RX7
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference