| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RH3 5DFR 1RX6 1DYJ 1JOM 1RX5 2D0K 1RB2 2ANO 1JOL 1DHI 1RA1 1DHJ 3OCH 1DYI 1RX4 1RX3 1DDR 1DRH 1RX8 1RF7 1RE7 1DRA 7DFR 1DRB 2INQ 2ANQ 1RX1 3QL3 3DRC 1RA3 1DRE 1RC4 1RX7 6DFR 3DAU 1DYH 2DRC 1RA8 1RA2 1DDS 3K74 1RX2 1RB3 1RD7 1RX9 4DFR 1RA9 1RG7 3KFY 1TDR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |