| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0042493 | response to drug | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RE7 1RD7 1DYJ 2DRC 1DRA 7DFR 1JOL 3KFY 1RA3 1RA8 1RC4 6DFR 1RB3 1TDR 1RG7 1RF7 1DRE 1RX8 1DDS 2INQ 1RX7 4DFR 3DRC 1RX9 2ANQ 1DYI 1DRB 1RH3 3DAU 1JOM 1RX6 1RA1 3OCH 1DDR 3K74 1RA2 1RX4 1RX3 1DHJ 5DFR 1RB2 1DYH 2D0K 1DRH 1RX5 1RA9 1DHI 3QL3 1RX2 2ANO 1RX1 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |