| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0042493 | response to drug | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
2ANO 3OCH 1TDR 1RB3 1RB2 1DYI 1RA9 1DRE 1DRB 5DFR 1DDR 3DRC 1DDS 3QL3 1RX6 1DHI 1RD7 1RX2 4DFR 1RX3 1RX8 1RC4 1DRA 1RF7 1JOL 1RA1 1RA8 1DYH 1RX9 2D0K 1DYJ 1RH3 1RG7 2ANQ 1JOM 1DHJ 1DRH 2DRC 1RA2 1RX5 1RX4 3K74 1RX7 3DAU 7DFR 1RE7 1RA3 3KFY 2INQ 1RX1 6DFR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |