| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0042493 | response to drug | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
6DFR 1RA3 2INQ 1RX1 3KFY 2DRC 1DDR 1DHJ 1RA2 1RD7 1DYH 2ANO 1DRB 5DFR 1DRA 1RX4 1RA1 1RA9 1RG7 1RH3 1RC4 1RX2 3OCH 1RB2 1RX6 1TDR 1DYJ 1RB3 7DFR 1JOM 1RX5 3DAU 1RX8 1RX7 2D0K 1RF7 1DHI 3QL3 3DRC 1DRE 1DRH 1DYI 1JOL 1DDS 1RA8 1RX3 4DFR 3K74 1RE7 2ANQ 1RX9 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |