dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427	response to methotrexate	BP
GO:0006545	glycine biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0006730	one-carbon metabolic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RA8 1RX7 3DRC 1DDS 3KFY 1RC4 1JOL 1RX8 3OCH 1RA2 1JOM 6DFR 2ANO 2DRC 1RA3 1RE7 1RB3 1DRE 3QL3 1DHI 2INQ 1DRA 1DYI 1RF7 4DFR 1RX6 1TDR 7DFR 1DYH 1RX5 2D0K 1RG7 1RH3 1RD7 1DYJ 1RX2 1DDR 5DFR 1RX1 1RA9 2ANQ 1RX9 1DRB 1RB2 1RA1 3DAU 1DHJ 1DRH 3K74 1RX3 1RX4
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference