dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0042493	response to drug	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0006545	glycine biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0046677	response to antibiotic	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	3OCH 1RA2 3KFY 1DRE 1DYH 1DRA 4DFR 3QL3 1JOL 3DAU 1DRB 1RB2 1RX1 1RA9 1TDR 1DYI 1RX7 1RX2 1RX3 1RD7 1RA3 1RA1 1RX9 1DDR 1JOM 6DFR 1RX5 1RX6 1RX4 2ANQ 1DRH 2ANO 1DHJ 7DFR 1RA8 3DRC 3K74 1DHI 1RG7 2INQ 2D0K 1RB3 1RF7 1RH3 5DFR 1RC4 2DRC 1RE7 1DYJ 1DDS 1RX8
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference