dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0031427	response to methotrexate	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0046677	response to antibiotic	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DHI 1DHJ 3DAU 1RE7 2INQ 1RA9 6DFR 1RX4 1RC4 1RX1 1DRH 1TDR 1DDS 2ANQ 3K74 1JOM 1JOL 3OCH 7DFR 1DRB 1DDR 1DRA 5DFR 1RX2 1RX3 1RH3 1RG7 1RD7 1RA2 2ANO 1RA8 3DRC 2D0K 1DYI 1RX8 1RB2 1RA1 1DYJ 2DRC 1RX6 1RB3 3QL3 1RA3 1DRE 3KFY 1DYH 4DFR 1RX7 1RF7 1RX5 1RX9
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference