| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0042493 | response to drug | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RX7 1RX3 1JOL 2DRC 1RH3 2ANO 1RX5 3KFY 1DRE 1DYI 1RF7 1RA8 1RE7 1RA9 1RA2 1DDR 3QL3 1DYH 1RX9 1RC4 3OCH 1RG7 1RB2 2ANQ 1DHJ 5DFR 1DRH 1DRB 1RD7 1RA3 1DHI 1DDS 1RA1 1JOM 2D0K 1TDR 1RX8 3DAU 2INQ 3K74 1DRA 1RX2 1DYJ 1RX6 6DFR 1RX4 3DRC 4DFR 1RB3 7DFR 1RX1 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |