| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0050661 | NADP binding | MF |
| GO:0042493 | response to drug | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RE7 1RD7 1DDS 1RX5 3KFY 1RC4 1RA1 3DRC 1DRA 1RX6 1RG7 4DFR 1DHJ 1RX3 1DRE 1RF7 1JOM 7DFR 1DDR 1RX1 1RA8 1DYH 2DRC 1RA9 1RX7 1RA3 3QL3 1RX8 1DRH 2D0K 3K74 2INQ 1RH3 1DRB 1DYI 1JOL 1RA2 1TDR 1RX4 1RX2 5DFR 1DHI 2ANQ 2ANO 1RB3 1RB2 1DYJ 3OCH 3DAU 1RX9 6DFR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |