dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427	response to methotrexate	BP
GO:0006545	glycine biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0050661	NADP binding	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	2ANQ 1RX9 3DAU 1RG7 1RE7 1RH3 1DHI 2ANO 5DFR 1DYH 1RX5 1DYJ 1RX8 1DRH 1RX7 1RA1 1JOL 1TDR 1RX1 3QL3 1JOM 1RB2 2DRC 1RX2 3KFY 1RX4 1RB3 7DFR 1DRB 1DHJ 1RA3 1RC4 3OCH 1RF7 2D0K 1RA9 1RA2 4DFR 1DRE 3DRC 1RX6 1DYI 3K74 1DDR 1RX3 2INQ 1DRA 1RD7 6DFR 1RA8 1DDS
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

Options for BLAST

Database:

Set subsequence:(optional):

Optional parameters:

Database Cross Reference