dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006730	one-carbon metabolic process	BP
GO:0042493	response to drug	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0006545	glycine biosynthetic process	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RA3 1DDR 1JOL 1DDS 1RB3 3KFY 1DHJ 1RA2 1DYJ 3DAU 3QL3 2INQ 3OCH 1DRH 2ANQ 1RX7 5DFR 6DFR 4DFR 1RX8 1RF7 1RH3 2ANO 1RX9 3K74 1RA9 1DYH 1RA8 1RX4 7DFR 1RD7 2D0K 1TDR 1RA1 1DRE 1DRA 1RC4 1RX3 1RX2 1RG7 1DRB 3DRC 1RX6 1RB2 2DRC 1DHI 1JOM 1RX1 1DYI 1RE7 1RX5
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference