| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1JOL 1DRA 1DHI 1RA1 1DDR 1RF7 3QL3 5DFR 3OCH 4DFR 1TDR 1RH3 3KFY 1RA2 2D0K 1RX8 2INQ 1DHJ 1RX5 1RA9 3DAU 2ANO 1DYI 1DRB 1RX4 1RX9 1RB2 1RD7 1DRE 1JOM 1DYH 2DRC 6DFR 1RG7 1DRH 1DYJ 1RC4 3K74 1RX7 1RE7 1RB3 1RX3 2ANQ 1RX1 1RA3 3DRC 1RA8 7DFR 1RX2 1RX6 1DDS |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |