dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0006730	one-carbon metabolic process	BP
GO:0050661	NADP binding	MF
GO:0042493	response to drug	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0046677	response to antibiotic	BP
GO:0009165	nucleotide biosynthetic process	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	3DRC 1RB2 1DRB 1RX3 1RF7 1RX1 6DFR 1DYJ 1RA9 1JOM 1RX7 1RE7 1RH3 1RC4 1RA2 1RA8 1RB3 1JOL 4DFR 1DRA 1RA1 1DHI 1TDR 2D0K 1RG7 7DFR 1DYI 1RX9 5DFR 3K74 1RX2 3DAU 1DDR 3KFY 2ANO 2ANQ 1RX4 1RX5 1RA3 3QL3 1DRH 2DRC 1DYH 1RX6 3OCH 1RX8 1RD7 2INQ 1DDS 1DHJ 1DRE
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

Options for BLAST

Database:

Set subsequence:(optional):

Optional parameters:

Database Cross Reference