dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0050661	NADP binding	MF
GO:0006730	one-carbon metabolic process	BP
GO:0031427	response to methotrexate	BP
GO:0046677	response to antibiotic	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0006545	glycine biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0042493	response to drug	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RA8 1RX2 4DFR 1JOM 1TDR 1RX8 1DYJ 1RD7 1RB2 2ANO 1DHJ 1DDR 6DFR 1JOL 1RX6 1DRA 1DDS 1DRH 1RX1 2DRC 1DRB 3OCH 7DFR 3DAU 5DFR 2D0K 1RX9 3KFY 1RG7 1RH3 3DRC 1RA3 1RX3 1RA9 1DYI 1RX4 3QL3 1RX7 1RA2 1DRE 1RB3 2INQ 3K74 1RF7 1RC4 1RX5 1DYH 1DHI 2ANQ 1RE7 1RA1
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference