| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0042493 | response to drug | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
7DFR 1DYJ 1RC4 1RX8 3QL3 1DHJ 1DYI 1RF7 1DRE 2DRC 1RX6 1DDR 1RH3 3OCH 3K74 1RA3 1RX1 1DRB 1RE7 5DFR 1JOM 1RX2 4DFR 1RX9 2D0K 1RX7 1RX4 3DAU 1RA8 1DHI 1DDS 2ANQ 1DRA 1RD7 1DYH 1RG7 1RA1 1DRH 1RA2 6DFR 1RB2 1RX5 2ANO 3KFY 3DRC 1RX3 2INQ 1RB3 1JOL 1RA9 1TDR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |