| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0050661 | NADP binding | MF |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1DDR 1RX3 1DRB 1JOL 1RX2 1RX8 1RX1 1RX4 1RX9 3KFY 2D0K 1DYH 1RX5 1DHI 1DYJ 2ANQ 1RG7 1RX6 1RA2 2ANO 1RA8 3DAU 1RE7 1RA1 1DYI 5DFR 1RB3 1DHJ 4DFR 1RH3 1RA9 1DRH 2INQ 3QL3 1DRA 1RD7 1DRE 1JOM 1TDR 3OCH 1RC4 6DFR 3DRC 3K74 2DRC 1RA3 1RF7 1RX7 1RB2 1DDS 7DFR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |