dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0004146	dihydrofolate reductase activity	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0031427	response to methotrexate	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0046677	response to antibiotic	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX5 2ANQ 3KFY 1RB2 1RX9 2ANO 2INQ 1RA1 1DYJ 4DFR 3DRC 1RA9 1RX7 1RA3 1DRE 1DRH 1RX2 3DAU 1RD7 2D0K 1DRB 5DFR 1DHJ 1RX3 1RE7 3QL3 1DDS 1RC4 1DDR 1DRA 1RG7 1RX6 2DRC 1JOM 1RH3 1DYI 1RF7 1TDR 7DFR 3K74 1DYH 1RA8 1RX1 1JOL 1RX4 1DHI 1RA2 1RB3 1RX8 3OCH 6DFR
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference