| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RG7 1RX2 7DFR 1RF7 2INQ 1JOM 1RD7 1RA9 1RX6 1DRB 1RX9 1RX8 2ANQ 1RA2 2D0K 6DFR 1JOL 3OCH 1RX7 1RB2 3KFY 1RC4 1RE7 1RB3 5DFR 3DRC 1RX4 1DHJ 1TDR 1DRE 1RX3 1DRH 1RA3 1DDR 4DFR 1DYJ 2DRC 1DYI 3DAU 1DDS 1RA1 1RH3 3K74 1DYH 1DRA 1RX5 3QL3 2ANO 1RA8 1RX1 1DHI |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |