dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0050661	NADP binding	MF
GO:0042493	response to drug	BP
GO:0031427	response to methotrexate	BP
GO:0046677	response to antibiotic	BP
GO:0004146	dihydrofolate reductase activity	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DDR 1RX2 1JOL 2DRC 1RA1 1RX4 1DYJ 1RD7 1RG7 1RX3 7DFR 1DYH 1RA9 1RX9 2ANO 3DRC 1RE7 1DHJ 3KFY 1RX6 1RA3 3QL3 1RA2 2INQ 1RF7 1DYI 3DAU 1DRB 2D0K 3K74 1RX5 1RB3 3OCH 1DRA 1RX7 1DDS 1RA8 1DRE 1TDR 2ANQ 5DFR 1RC4 1DHI 6DFR 1JOM 1DRH 1RH3 1RX8 1RB2 1RX1 4DFR
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference