| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0042493 | response to drug | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
3OCH 1RA3 1RA9 1RX6 1DYH 1RB3 1DRE 1RX8 1DDS 1RX7 4DFR 6DFR 1RC4 1DHI 1DHJ 1RX9 2DRC 1RF7 2INQ 1RB2 1TDR 3KFY 7DFR 1RA1 1DRH 3DAU 1RX3 1DRB 3K74 1JOL 2ANO 5DFR 1RH3 1RE7 1RX1 2D0K 1RX2 1DYJ 2ANQ 1RX4 3DRC 1RA2 1DRA 1RG7 1JOM 3QL3 1RD7 1RX5 1RA8 1DDR 1DYI |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |