| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1DRH 1DYI 3DAU 1RB3 1RX5 1DDR 1RH3 1DRE 1RX6 3KFY 1RX4 1RG7 1DDS 1DRB 2ANO 1RF7 1RA3 6DFR 1RX9 1RD7 3K74 4DFR 1RE7 1RA8 1JOM 1RC4 2ANQ 1RB2 3DRC 1JOL 2DRC 1RX1 5DFR 1RX2 1DRA 1RX8 1DYJ 1RA1 1TDR 2INQ 2D0K 7DFR 1RX3 1DHI 1RA9 1RA2 1DHJ 1DYH 3QL3 1RX7 3OCH |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |