dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0004146	dihydrofolate reductase activity	MF
GO:0050661	NADP binding	MF
GO:0006730	one-carbon metabolic process	BP
GO:0046677	response to antibiotic	BP
GO:0042493	response to drug	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0031427	response to methotrexate	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	2DRC 3DRC 1DYI 1DYJ 1RX8 2D0K 1DYH 1RA3 1DRB 1RH3 1RC4 2INQ 7DFR 1RX5 1RA8 3KFY 3K74 1RB3 1DRE 1RB2 1RF7 1JOL 1RA2 1RX6 2ANO 3QL3 1JOM 1RG7 1RD7 1RX9 4DFR 2ANQ 3DAU 1DHJ 1DRH 1RX4 1RE7 1DDR 6DFR 1DRA 1TDR 1RX7 1RX2 1DHI 1RX1 5DFR 1DDS 1RA9 1RA1 3OCH 1RX3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference