dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006730	one-carbon metabolic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0031427	response to methotrexate	BP
GO:0050661	NADP binding	MF
GO:0046677	response to antibiotic	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0042493	response to drug	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX4 1RH3 1DDR 1RA2 6DFR 1DYH 1RX5 1DYJ 1DYI 1JOL 2ANQ 1TDR 1RA9 1RX8 1RX7 1RX1 1RD7 1DHJ 1DRA 1JOM 1DDS 1RG7 2D0K 4DFR 1RX3 3OCH 1RA3 3KFY 1DRB 1DRH 3K74 3DRC 3QL3 1RX2 2INQ 2DRC 1RC4 1RX9 1RA1 1RA8 1DHI 2ANO 1RE7 1RB2 7DFR 1RX6 5DFR 1RB3 1DRE 1RF7 3DAU
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference