dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0042493	response to drug	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0004146	dihydrofolate reductase activity	MF
GO:0046677	response to antibiotic	BP
GO:0006545	glycine biosynthetic process	BP
GO:0031427	response to methotrexate	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RB2 1TDR 1RA2 1RE7 1DRB 1DRH 1DDS 1RA1 1RX9 1DYH 1RH3 1RA3 3QL3 1DHI 1RX8 1DDR 3KFY 1RB3 1RX1 1DRE 3DAU 2ANO 1DHJ 1RX2 1RF7 3K74 1RX3 2INQ 3DRC 1RG7 2D0K 5DFR 1JOM 2ANQ 1DYI 6DFR 1RC4 1RX4 1DRA 1RX5 1RA8 1DYJ 1RX6 1RX7 4DFR 1JOL 2DRC 7DFR 3OCH 1RA9 1RD7
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference