| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0031427 | response to methotrexate | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
7DFR 1DYH 1RX5 2ANO 3KFY 1RX4 1DRB 1DRE 1RX7 1DYJ 5DFR 1JOL 3K74 1RC4 2ANQ 3QL3 3OCH 3DAU 1RG7 1RX1 1TDR 1RA8 2INQ 3DRC 4DFR 1RD7 1DRA 1DDR 1RE7 1RB3 1DRH 1RH3 6DFR 1RX3 1RX6 1RX9 1DDS 1RX8 2D0K 1RA9 1JOM 1RX2 1RB2 1DYI 2DRC 1RA3 1RF7 1RA1 1DHI 1RA2 1DHJ |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |