dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006730	one-carbon metabolic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0004146	dihydrofolate reductase activity	MF
GO:0006545	glycine biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0046677	response to antibiotic	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0042493	response to drug	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RA1 1RX9 3K74 3DRC 1DDR 3KFY 1DRB 3OCH 6DFR 1RX6 2INQ 1DRH 1RA9 1JOM 3QL3 1RB3 1RX2 1RX5 1RF7 1DRA 1RX8 1RA2 1DYI 1RH3 1RA8 7DFR 1RA3 1DRE 2DRC 2ANO 1RB2 3DAU 1DYJ 1TDR 1RD7 1RX4 4DFR 1RE7 1JOL 1DYH 1DHI 1RC4 1RX7 1DDS 1RX3 2D0K 2ANQ 1RG7 5DFR 1RX1 1DHJ
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference