dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0050661	NADP binding	MF
GO:0006730	one-carbon metabolic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0031427	response to methotrexate	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0042493	response to drug	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX7 1RA2 3DRC 1RA1 1RB2 1DDS 1RA8 1RH3 5DFR 6DFR 2D0K 3KFY 1RG7 2INQ 1RX5 1JOL 1DRE 2ANO 3QL3 1RX4 1DDR 4DFR 1RX3 1TDR 2ANQ 1DRA 1RF7 1DRB 1RA9 1RB3 1RE7 1RD7 1DYH 1RX8 1DHJ 1DYJ 1RX6 2DRC 7DFR 1RA3 1JOM 3K74 1DRH 1RC4 1RX2 1DYI 1RX9 3DAU 1DHI 1RX1 3OCH
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference