dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0046677	response to antibiotic	BP
GO:0006730	one-carbon metabolic process	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DRB 1RB2 1DDS 3OCH 2D0K 1RF7 3DAU 2DRC 6DFR 3KFY 1RX1 1RX3 1DDR 4DFR 1RD7 1DHJ 2ANO 5DFR 1RX8 1RE7 1DYI 3DRC 1DYH 3K74 1RB3 1RG7 1DYJ 1DRH 7DFR 1RH3 1RX9 1DHI 1RX5 1RA8 1RX4 1RA9 1RA1 1TDR 1RA2 1RX6 1RX2 2INQ 2ANQ 1RC4 1RA3 1RX7 1DRE 1DRA 1JOL 1JOM 3QL3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

Options for BLAST

Database:

Set subsequence:(optional):

Optional parameters:

Database Cross Reference