calmodulin

General Information (Source: NCBI Gene,UniProt)

Text mining Term calmodulin
UniProt ID CALM_RAT
Name CaM
Calmodulin
Gene Names Calm3
Taxonomy Rattus norvegicus

General annotation

Function Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+), AND MASS SPECTROMETRY. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
Subcellular location Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules (By similarity).

Gene Ontology

GO:0048306 calcium-dependent protein binding MF
GO:0000922 spindle pole CC
GO:0043548 phosphatidylinositol 3-kinase binding MF
GO:0005246 calcium channel regulator activity MF

Sequence

>gi|6978591|ref|NP_036650.1| calmodulin [Rattus norvegicus]
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL
TMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYE
EFVQMMTAK

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Database Cross Reference

Ensembl Gene ENSRNOT00000022603
ENSRNOT00000064679
UniGene Rn.2892
Rn.5968
Rn.216430
Rn.4166
PDB 2PQ3
1QX5
3BXL
3CLN
3EVU
3EK8
1G4Y
2HQW
3EVR
1NIW
1QX7
2YGG
3EK4
3EKJ
3BXK
3B32
3EKH
3EVV
3EK7
3IFK
RefSeq NP_036650.1
NP_059022.1
NP_114175.1
Pfam PF00036