calmodulin

General Information (Source: NCBI Gene,UniProt)

Text mining Term	calmodulin
UniProt ID	CALM_RAT
Name	CaM Calmodulin
Gene Names	Calm3
Taxonomy	Rattus norvegicus

General annotation

Function	Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+), AND MASS SPECTROMETRY. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).
Subcellular location	Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules (By similarity).

Function

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+), AND MASS SPECTROMETRY. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).

Subcellular location

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules (By similarity).

Gene Ontology

GO:0043548	phosphatidylinositol 3-kinase binding	MF
GO:0000922	spindle pole	CC
GO:0005246	calcium channel regulator activity	MF
GO:0048306	calcium-dependent protein binding	MF

Sequence

>gi|14010863|ref|NP_114175.1| calmodulin [Rattus norvegicus]
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFL
TMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYE
EFVQMMTAK

Database Cross Reference

Ensembl Gene	ENSRNOT00000022603 ENSRNOT00000064679
UniGene	Rn.4166 Rn.5968 Rn.216430 Rn.2892
PDB	3IFK 3EVU 1G4Y 3EVV 3EKJ 3EK4 3EK8 2HQW 3EK7 1NIW 1QX7 2PQ3 3CLN 2YGG 3BXL 1QX5 3EVR 3EKH 3BXK 3B32
RefSeq	NP_036650.1 NP_114175.1 NP_059022.1
Pfam	PF00036

PTID

calmodulin

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference