kynurenine aminotransferase I

General Information (Source: NCBI Gene,UniProt)

Text mining Term kynurenine aminotransferase I
UniProt ID KAT1_MOUSE
Name KATI
Kynurenine aminotransferase I
GTK
Kynurenine--oxoglutarate transaminase 1
Glutamine transaminase K
Glutamine--phenylpyruvate transaminase
Kynurenine--oxoglutarate transaminase I
Cysteine-S-conjugate beta-lyase
Gene Names Ccbl1
Synonyms:Kat
Taxonomy Mus musculus

General annotation

Function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity).
Subcellular location Cytoplasm (By similarity).

Gene Ontology

GO:0047316 glutamine-phenylpyruvate transaminase activity MF
GO:0030170 pyridoxal phosphate binding MF
GO:0005737 cytoplasm CC
GO:0016212 kynurenine-oxoglutarate transaminase activity MF
GO:0047804 cysteine-S-conjugate beta-lyase activity MF
GO:0070189 kynurenine metabolic process BP
GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity MF

Sequence

>gi|31982063|ref|NP_765992.2| kynurenine--oxoglutarate transaminase 1 [Mus musculus]
MSKQLQARRLEGIDHNPWVEFTRLSKEYDVVNLGQGFPDFSPPDFAVQAFQQATTGNFMLNQYTSAFGYP
PLTKILASFFGKLLGQEMDPLKNVLVTVGAYGALFTAFQALVDEGDEVIIIEPAFNCYEPMTMMAGGRPV
FVSLRLSPAPKGQLGSSNDWQLDPTELASKFTPRTKILVLNTPNNPLGKVFSKKELELVAALCQQHDVLC
FSDEVYQWLVYDGHQHISIASLPGMWERTLTIGSAGKSFSATGWKVGWVMGPDNIMKHLRTVHQNSIFHC
PTQAQAAVAQCFEREQQHFGQPSSYFLQLPQAMGLNRDHMIQSLQSVGLKPLIPQGSYFLIADISDFKSS
MPDLPGAMDEPYDTRFAKWMIKNKGLSAIPVSTFYSQPHHKDFDHYIRFCFVKDKATLQAMDKRLCSWKG
EPQA

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Database Cross Reference

Ensembl Gene ENSMUST00000044038
ENSMUST00000113663
ENSMUST00000113661
ENSMUST00000113662
UniGene Mm.216089
PDB
RefSeq NP_765992.2
Pfam PF00155