cystathionine beta synthase

General Information (Source: NCBI Gene,UniProt)

Text mining Term cystathionine beta synthase
UniProt ID CBS_RAT
Name Beta-thionase
Serine sulfhydrase
Cystathionine beta-synthase
Hemoprotein H-450
Gene Names Cbs
Taxonomy Rattus norvegicus

General annotation

Function Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
Subcellular location Nucleus (By similarity). Cytoplasm.

Gene Ontology

GO:0019346 transsulfuration BP
GO:0005625 soluble fraction CC
GO:0006535 cysteine biosynthetic process from serine BP
GO:0030170 pyridoxal phosphate binding MF
GO:0071456 cellular response to hypoxia BP
GO:0004122 cystathionine beta-synthase activity MF
GO:0070814 hydrogen sulfide biosynthetic process BP
GO:0019343 cysteine biosynthetic process via cystathionine BP
GO:0043066 negative regulation of apoptotic process BP

Sequence

>gi|158186659|ref|NP_036654.2| cystathionine beta-synthase [Rattus norvegicus]
MPSGTSQCEDGSAGCPQDLEVQPEKGQLEKGASGDKERVWISPDTPSRCTWQLGRPMADSPHYHTVPTKS
PKILPDILRKIGNTPMVRINRISKNAGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERAGTLKPGDTII
EPTSGNTGIGLALAAAVKGYRCIIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNE
IPNSHILDQYRNASNPLAHYDDTAEEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDPE
GSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQEGLLCGGSSGSA
MAVAVKAAQELKEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFMKEELSVKRPWWWHLRVQELSLSAPLT
VLPTVTCEHTIAILREKGFDQAPVVNESGAILGMVTLGNMLSSLLAGKVRPSDEVCKVLYKQFKPIHLTD
TLGMLSHILEMDHFALVVHEQIQYRNNGVSSKQLMVFGVVTAIDLLNFVAAREQTRK

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.87853
PDB
RefSeq NP_036654.2
Pfam PF00571
PF00291