caspase 3

General Information (Source: NCBI Gene,UniProt)

Text mining Term caspase 3
UniProt ID CASP3_RAT
Name SCA-1
Caspase-3 subunit p17
Caspase-3 subunit p12
LICE
IRP
Caspase-3
SREBP cleavage activity 1
Protein Yama
Apopain
Cysteine protease CPP32
CPP-32
CASP-3
Gene Names Casp3
Synonyms:Cpp32
Taxonomy Rattus norvegicus

General annotation

Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (By similarity).
Subcellular location Cytoplasm.

Gene Ontology

GO:0032025 response to cobalt ion BP
GO:0006508 proteolysis BP
GO:0030182 neuron differentiation BP
GO:0005829 cytosol CC
GO:0032496 response to lipopolysaccharide BP
GO:0043200 response to amino acid stimulus BP
GO:0046677 response to antibiotic BP
GO:0007611 learning or memory BP
GO:0016005 phospholipase A2 activator activity MF
GO:0004197 cysteine-type endopeptidase activity MF
GO:0035556 intracellular signal transduction BP
GO:0042060 wound healing BP
GO:0034349 glial cell apoptosis BP
GO:0021766 hippocampus development BP
GO:0005625 soluble fraction CC
GO:0035094 response to nicotine BP
GO:0001666 response to hypoxia BP
GO:0042542 response to hydrogen peroxide BP
GO:0032355 response to estradiol stimulus BP
GO:0042493 response to drug BP
GO:0043525 positive regulation of neuron apoptosis BP
GO:0051384 response to glucocorticoid stimulus BP
GO:0006917 induction of apoptosis BP
GO:0009749 response to glucose stimulus BP
GO:0005515 protein binding MF
GO:0010165 response to X-ray BP

Sequence

>gi|6978605|ref|NP_037054.1| caspase-3 [Rattus norvegicus]
MDNNETSVDSKSINNFETKTIHGSKSMDSGIYLDSSYKMDYPEMGLCIIINNKNFHKSTGMSARNGTDVD
AANLRETFMALKYEVRNKNDLTREEIMELMDSVSKEDHSKRSSFVCVILSHGDEGVIFGTNGPVDLKKLT
SFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSR
DGSWFIQSLCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFYH

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Database Cross Reference

Ensembl Gene ENSRNOT00000014095
UniGene Rn.10562
PDB
RefSeq NP_037054.1
Pfam PF00656