| Text mining Term | progesterone receptor |
|---|---|
| UniProt ID | PRGR_RAT |
| Name |
Nuclear receptor subfamily 3 group C member 3 Progesterone receptor PR |
| Gene Names |
Pgr
Synonyms:Nr3c3 |
| Taxonomy | Rattus norvegicus |
| Function |
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform is involved in activation of c-SRC/MAPK signaling on hormone stimulation (By similarity). |
|---|---|
| Subcellular location |
Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity). |
| GO:0008270 | zinc ion binding | MF |
| GO:0005829 | cytosol | CC |
| GO:0016101 | diterpenoid metabolic process | BP |
| GO:0042562 | hormone binding | MF |
| GO:0006351 | transcription, DNA-dependent | BP |
| GO:0071373 | cellular response to luteinizing hormone stimulus | BP |
| GO:0045893 | positive regulation of transcription, DNA-dependent | BP |
| GO:0045892 | negative regulation of transcription, DNA-dependent | BP |
| GO:0005496 | steroid binding | MF |
| GO:0071372 | cellular response to follicle-stimulating hormone stimulus | BP |
| GO:0003707 | steroid hormone receptor activity | MF |
| GO:0005634 | nucleus | CC |
| GO:0043005 | neuron projection | CC |
| GO:0043565 | sequence-specific DNA binding | MF |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | MF |
| GO:0001553 | luteinization | BP |
>gi|12408292|ref|NP_074038.1| progesterone receptor [Rattus norvegicus] MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQEL PDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSW CLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGV KPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRV SLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSP PVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPP RPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLP AAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLIC GDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK KFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDT SSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP DLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIR ELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKI LAGMVKPLLFHKK |
| Ensembl Gene | |
|---|---|
| UniGene |
Rn.10303 |
| PDB | |
| RefSeq |
NP_074038.1 |
| Pfam |
PF02161 PF00104 PF00105 |