NR2B

General Information (Source: NCBI Gene,UniProt)

Text mining Term NR2B
UniProt ID NMDE2_RAT
Name NR2B
Glutamate [NMDA] receptor subunit epsilon-2
NMDAR2B
N-methyl D-aspartate receptor subtype 2B
Gene Names Grin2b
Taxonomy Rattus norvegicus

General annotation

Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Subcellular location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0033555 multicellular organismal response to stress BP
GO:0005234 extracellular-glutamate-gated ion channel activity MF
GO:0021766 hippocampus development BP
GO:0051592 response to calcium ion BP
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity MF
GO:0014049 positive regulation of glutamate secretion BP
GO:0048511 rhythmic process BP
GO:0008306 associative learning BP
GO:0008270 zinc ion binding MF
GO:0051602 response to electrical stimulus BP
GO:0009612 response to mechanical stimulus BP
GO:0043083 synaptic cleft CC
GO:0030018 Z disc CC
GO:0071230 cellular response to amino acid stimulus BP
GO:0045471 response to ethanol BP
GO:0008013 beta-catenin binding MF
GO:0021987 cerebral cortex development BP
GO:0008144 drug binding MF
GO:0009743 response to carbohydrate stimulus BP
GO:0060416 response to growth hormone stimulus BP
GO:0071407 cellular response to organic cyclic compound BP
GO:0010350 cellular response to magnesium starvation BP
GO:0071359 cellular response to dsRNA BP
GO:0042734 presynaptic membrane CC
GO:0030054 cell junction CC
GO:0050839 cell adhesion molecule binding MF
GO:0060992 response to fungicide BP
GO:0035235 ionotropic glutamate receptor signaling pathway BP
GO:0032026 response to magnesium ion BP
GO:0042165 neurotransmitter binding MF
GO:0035255 ionotropic glutamate receptor binding MF
GO:0030288 outer membrane-bounded periplasmic space CC
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex CC
GO:0034097 response to cytokine stimulus BP
GO:0014069 postsynaptic density CC
GO:0071396 cellular response to lipid BP
GO:0043195 terminal button CC
GO:0001508 regulation of action potential BP
GO:0071363 cellular response to growth factor stimulus BP
GO:0010942 positive regulation of cell death BP
GO:0046982 protein heterodimerization activity MF
GO:0071287 cellular response to manganese ion BP
GO:0001975 response to amphetamine BP
GO:0031749 D2 dopamine receptor binding MF
GO:0050806 positive regulation of synaptic transmission BP
GO:0048169 regulation of long-term neuronal synaptic plasticity BP
GO:0043113 receptor clustering BP
GO:0043408 regulation of MAPKKK cascade BP
GO:0051597 response to methylmercury BP
GO:0051707 response to other organism BP
GO:0007616 long-term memory BP
GO:0045211 postsynaptic membrane CC
GO:0042220 response to cocaine BP

Sequence

>gi|6980984|ref|NP_036706.1| glutamate [NMDA] receptor subunit epsilon-2 precursor [Rattus norvegicus]
MKPSAECCSPKFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGTSDEVAIKDAHEKDDFHHLSVVPRVEL
VAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDES
SMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLD
DGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTGLISV
SYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLS
FSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVE
SVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI
NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWV
MMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI
MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYA
EMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDS
GWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH
LFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMAN
LSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNV
YQDHYHHHHRPHSIGSTSSIDGLYDCDNPPFTTQPRSISKKPLDIGLPSSKHSQLSDLYGKFSFKSDRYS
GHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHK
RYFRDKEGLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHLKHGTGEKHGVV
GGVPAPWEKNLTNVDWEDRSGGNFCRSCPSKLHNYSSTVAGQNSGRQACIRCEACKKAGNLYDISKDNSL
QELDQPAAPVAVTSNASSTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPRSVSLKDKGRF
MDGSPYAHMFEMPAGESSFANKSSVPTAGHHHNNPGSGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHGSK
SYFFRQPTVAGASKTRPDFRALVTNKPVVSALHGAVPGRFQKDICIGNQSNPCVPNNKNPRAFNGSSNGH
VYEKLSSIESDV

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.9711
PDB 3QEL
3QEM
3JPY
3JPW
RefSeq NP_036706.1
Pfam PF01094
PF10565
PF00497
PF00060