alpha 1A adrenoceptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term alpha 1A adrenoceptor
UniProt ID ADA1A_RAT
Name Alpha-1A adrenergic receptor
Alpha-1C adrenergic receptor
Alpha-1A adrenoreceptor
Alpha-1A adrenoceptor
Gene Names Adra1a
Synonyms:Adra1c
Taxonomy Rattus norvegicus

General annotation

Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0032229 negative regulation of synaptic transmission, GABAergic BP
GO:0005886 plasma membrane CC
GO:0090037 positive regulation of protein kinase C signaling cascade BP
GO:0016021 integral to membrane CC
GO:0042493 response to drug BP
GO:0009725 response to hormone stimulus BP
GO:0060452 positive regulation of cardiac muscle contraction BP
GO:0004937 alpha1-adrenergic receptor activity MF
GO:0007568 aging BP
GO:0045760 positive regulation of action potential BP
GO:0035024 negative regulation of Rho protein signal transduction BP
GO:0006950 response to stress BP
GO:0070374 positive regulation of ERK1 and ERK2 cascade BP
GO:0060402 calcium ion transport into cytosol BP
GO:0045907 positive regulation of vasoconstriction BP

Sequence

>gi|148747171|ref|NP_058887.2| alpha-1A adrenergic receptor [Rattus norvegicus]
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAV
ADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQ
RRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVV
AKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGC
FVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQ
SSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACT
TARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV

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Database Cross Reference

Ensembl Gene ENSRNOT00000012736
UniGene Rn.9991
PDB 2F75
RefSeq NP_058887.2
Pfam PF00001