alcohol dehydrogenase (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term alcohol dehydrogenase (protein family or complex)
UniProt ID AK1A1_RAT
Name 3-DG-reducing enzyme
Aldehyde reductase
Alcohol dehydrogenase [NADP+]
Aldo-keto reductase family 1 member A1
Gene Names Akr1a1
Synonyms:Alr
Taxonomy Rattus norvegicus

General annotation

Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Catalyzes the NADPH-dependent reduction of 3-deoxyglucosone (3-DG).
Subcellular location

Gene Ontology

GO:0008106 alcohol dehydrogenase (NADP+) activity MF

Sequence

>gi|13591894|ref|NP_112262.1| alcohol dehydrogenase [NADP+] [Rattus norvegicus]
MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKAV
PREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVKYDSTHY
KETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAY
SPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFT
FSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY

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Database Cross Reference

Ensembl Gene ENSRNOT00000023072
UniGene Rn.835
PDB
RefSeq NP_112262.1
Pfam PF00248