SK2

General Information (Source: NCBI Gene,UniProt)

Text mining Term SK2
UniProt ID KCNN2_RAT
Name SKCa 2
KCa2.2
Small conductance calcium-activated potassium channel protein 2
SKCa2
SK2
Gene Names Kcnn2
Taxonomy Rattus norvegicus

General annotation

Function Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Subcellular location Membrane; Multi-pass membrane protein.

Gene Ontology

GO:0016021 integral to membrane CC
GO:0016286 small conductance calcium-activated potassium channel activity MF
GO:0005516 calmodulin binding MF

Sequence

>gi|9506833|ref|NP_062187.1| small conductance calcium-activated potassium channel protein 2 [Rattus norvegicus]
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEH
NNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYAL
IFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAM
TYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKL
FTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAM
WLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRV
KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIM
YDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSR
SSSRRRRSSSTAPPTSSESS

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000022530
UniGene Rn.44421
PDB 1QX7
2PNV
1G4Y
1KKD
RefSeq NP_062187.1
Pfam PF02888
PF03530
PF07885