CaMK II

General Information (Source: NCBI Gene,UniProt)

Text mining Term	CaMK II
UniProt ID	KCC2G_MOUSE
Name	Calcium/calmodulin-dependent protein kinase type II subunit gamma CaMK-II subunit gamma CaM kinase II subunit gamma
Gene Names	Camk2g
Taxonomy	Mus musculus

General annotation

Function	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates to the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate to the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity).
Subcellular location	Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable).

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates to the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate to the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning (By similarity).

Subcellular location

Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable).

Gene Ontology

GO:0007399	nervous system development	BP
GO:0005516	calmodulin binding	MF
GO:0004683	calmodulin-dependent protein kinase activity	MF
GO:0033017	sarcoplasmic reticulum membrane	CC
GO:0006816	calcium ion transport	BP
GO:0000082	G1/S transition of mitotic cell cycle	BP
GO:0005524	ATP binding	MF
GO:0030154	cell differentiation	BP
GO:0046777	protein autophosphorylation	BP

Sequence

>gi|85362742|ref|NP_001034227.1| calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2 [Mus musculus]
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKH
PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPE
NLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVG
YPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVAS
MMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQ
TAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSF
EPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSE
ETRVWHRRDGKWLNVHYHCSGAPAAPLQ

Database Cross Reference

Ensembl Gene	ENSMUST00000080440 ENSMUST00000071816 ENSMUST00000100837
UniGene	Mm.235182
PDB
RefSeq	NP_001034227.1 NP_001034228.1 NP_848712.2
Pfam	PF08332 PF00069

PTID

CaMK II

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference