CaMK II

General Information (Source: NCBI Gene,UniProt)

Text mining Term CaMK II
UniProt ID KCC2A_MOUSE
Name CaM kinase II subunit alpha
Calcium/calmodulin-dependent protein kinase type II subunit alpha
CaMK-II subunit alpha
Gene Names Camk2a
Taxonomy Mus musculus

General annotation

Function CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Subcellular location Isoform Alpha KAP: Cytoplasm (Probable). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).

Gene Ontology

GO:0048168 regulation of neuronal synaptic plasticity BP
GO:0030054 cell junction CC
GO:0005524 ATP binding MF
GO:0005886 plasma membrane CC
GO:0005516 calmodulin binding MF
GO:0005954 calcium- and calmodulin-dependent protein kinase complex CC
GO:0005737 cytoplasm CC
GO:0046928 regulation of neurotransmitter secretion BP
GO:0000082 G1/S transition of mitotic cell cycle BP
GO:0046777 protein autophosphorylation BP
GO:0006816 calcium ion transport BP
GO:0035254 glutamate receptor binding MF
GO:0042734 presynaptic membrane CC
GO:0004683 calmodulin-dependent protein kinase activity MF
GO:0005515 protein binding MF

Sequence

>gi|6753250|ref|NP_033922.1| calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 precursor [Mus musculus]
MLLFLTLWALVPCLVLLTLYFLSSTGGKSGGNKKNDGVKKRKSSSSVQLMESSESTNTTIEDEDTKVRKQ
EIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPH
IHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH

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Database Cross Reference

Ensembl Gene ENSMUST00000102888
ENSMUST00000115295
UniGene Mm.131530
PDB 1HKX
RefSeq NP_033922.1
NP_803126.1
Pfam PF08332
PF00069