alcohol dehydrogenase (protein family or complex)

General Information (Source: NCBI Gene,UniProt)

Text mining Term alcohol dehydrogenase (protein family or complex)
UniProt ID AK1A1_MOUSE
Name Aldo-keto reductase family 1 member A1
Aldehyde reductase
Alcohol dehydrogenase [NADP+]
Gene Names Akr1a1
Synonyms:Akr1a4
Taxonomy Mus musculus

General annotation

Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).
Subcellular location

Gene Ontology

GO:0046185 aldehyde catabolic process BP
GO:0047939 L-glucuronate reductase activity MF
GO:0019853 L-ascorbic acid biosynthetic process BP
GO:0005829 cytosol CC
GO:0004032 alditol MF
GO:0016324 apical plasma membrane CC
GO:0042840 D-glucuronate catabolic process BP

Sequence

>gi|10946870|ref|NP_067448.1| alcohol dehydrogenase [NADP+] [Mus musculus]
MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAV
PREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHY
KETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAY
SPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFT
FSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY

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Database Cross Reference

Ensembl Gene ENSMUST00000030455
UniGene Mm.30085
PDB
RefSeq NP_067448.1
Pfam PF00248